2010
List of publications out of the research groups involved in the SFB
Shpacovitch V, Mertens PR.
Int Urol Nephrol. 2010 Sep;42(3):847-50.
Haase M, Mertens PR.
Urinary biomarkers--silver bullets to faster drug development and nephron protection.
Nephrol Dial Transplant. 2010 Oct;25(10):3167-9.
Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR.
YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
Biochem Biophys Res Commun. 2010 Jul 30;398(3):482-8.
Augstein A, Poitz DM, Braun-Dullaeus RC, Strasser RH, Schmeisser A.
Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells.
Cell Mol Life Sci.2010; 68:2627-2642.
Backes A, Seay U, Sedding DG, Tillmanns HH, Braun-Dullaeus RC.
Inhibition of matrix deposition: a new strategy for prevention of restenosis after balloon angioplasty. J Cardiovasc Pharmacol.2010; 55:213-218.
Medunjanin S, Weinert S, Poitz D, Schmeisser A, Strasser RH, Braun-Dullaeus RC. Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
EMBO Rep.2010;11:208-213.
Medunjanin S, Weinert S, Schmeisser A, Mayer D, Braun-Dullaeus RC. Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
Mol Biol Cell.2010; 21:1620-1628.
Willert M, Augstein A, Poitz DM, Schmeisser A, Strasser RH, Braun-Dullaeus RC.
Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation.
Basic Res Cardiol.2010; 105:267-277.
Schweitzer K, Sokolova O, Bozko PM, Naumann M.
Helicobacter pylori induces NF-қB independent of CagA.
EMBO Rep.2010; 11:10-11.
Rieke C, Kähne T, Schweitzer K, Schraven B, Wienands J, Engelke M, Naumann M.
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells.
Cell Signal.2010; 22:395-403.
Gnad T, Feoktistova M, Leverkus M, Lendeckel U, Naumann M.
Helicobacter pylori-induced activation of -catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.
Mol Cancer.2010; 9:31
Backert S, Naumann M
What a disorder: Pro-inflammatory signaling pathways induced by Helicobacter pylori.
Trends Microbiol. 2010,18:479-486. *Highlighted in Faculty of 1000 Biology.
Zenclussen ML, Thuere C, Ahmad N, Wafula PO, Fest S, Teles A, Leber A, Casalis PA, Bechmann I, Priller J, Volk HD, Zenclussen AC.
The persistence of paternal antigens in the maternal body is involved in regulatory T-cell expansion and fetal-maternal tolerance in murine pregnancy.
Am J Reprod Immunol. 2010;63(3):200-208.
Leber A, Teles A, Zenclussen AC.
Mechanisms of actions of regulatory T cells during pregnancy.
Am J Reprod Immunol.2010;63: 445-449.
Huang SJ, Zenclussen AC, Yang H, Basar M, Chen CO, Arcuri F, Li M, Kayisli U, Buchwalder L, Rahman M, Kocamaz E, Schatz F, Toti P, Lockwood CJ.
The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia.
Am J Pathol.2010; 177: 2472-2482.
Jensen F, Taran FA, Woudwyk M, Teles A, Woidacki K, Fill Malfertheiner S, Costa SD, Zenclussen AC.
Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and fetal- maternal interface as well as their maturation and degranulation.
Plos One.2010; 5: e14409.
Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E Thomas U.
A perisynaptic menage a trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
J Neurosci.2010; 30:5811-5824.
Licon Luna, RM, Körmendy D, Brunner-Weinzierl MC.
Female-biased incidence of Experimental Autoimmune Encephalomyelistis refects sexual dimorphic expression of CTLA-4 (CD152) on T-lymphocytes.
Gender Medicine.2010; 7: 296-308.
Schnee B, Marangolo M, Bokemeyer C, Deter HC, Freier E, Weber, CS, Nowottne U, Horn C, Meyer S, Hildebrandt Y, Luetkens T, Cao Y, Pabst C, Muzzulini J, Schnee B, Brunner-Weinzierl MC, Marangolo M, Deter HC, Atanackovic D.
Decrease of CD4(+)FOXP3(+) T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor.
Psychoneuroendocrinology.2010; 35:663-673.
Günther S, Schlundt A, Sticht J , Roske Y, Heinemann U, Wiesmüller KH, Jung G, Falk K, Rötzschke O, Freund C.
Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Proc Natl Acad Sci U S A.2010; 107:22219-24.
Zaminer J, Brockmann C, Huy P, Opitz R, Reuter C, Beyermann M, Freund C, Müller M, Oschkinat H, Kühne R, Schmalz HG.
Angew Chem Int Ed Engl. 2010; 49:7111-5.
Ash MR, Faelber K, Kosslick D, Albert GI, Roske Y, Kofler M, Schuemann M, Krause E, Freund C.
Structure.2010; 18:944-54.
Lange, S., M Sylvester, M Schümann, C Freund, and EJ Krause.
J Proteome Res.2010; 9:4113-22.
Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Großmann A, Stelzl, Ulrich, Schraven B, Krause E, Freund,C.
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
PLoS 2010; 5:7-18.
Rubio I, Grund S, Shu-Ping S, Biskup C, Bandemer S, Fricke M, Förster M, Graziani A,Wittig U, Kliche S.
TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-Ras.
J. Immunol. 2010; 185:3536-3543.
Albrecht, A., J Bergado, HC Pape and O Stork.
Role of the neural cell adhesion molecule NCAM in amygdalo-hippocampal interactions and salience determination of contextual fear memory.
Int. J. Neuropsychopharmacol.2010; 13:661-74.
Lindquist S, Langnaese K, Karitkina D, Lerch G, Schraven B, Xavier R, Seed B, Lindquist JA.
Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain development.
PLoS One,2010; 6(9):e23978.
Polansky JK*, Schreiber L*, Thelemann C, Ludwig L, Krüger M, Baumgrass R, Cording S, Floess S, Hamann A, Huehn J.
Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.
J Mol Med.2010; 88:1029-1040. (*equal contribution)
Klages K*, Mayer CT*, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J*, Sparwasser T*.
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Cancer Res.2010; 70:7788-7799. *equal contribution
Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S.
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
J Exp Med.2010; 207:2561-2568.
Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G.
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
Proc Natl Acad Sci U S A.2010; 107:204-209.
Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C, Hamann A, Huehn J.
Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation.
Eur J Immuno.,2010:40:2539-2548.
Doebis C, Menning A, Neumann K, Ghani S, Schlawe K, Lauer U, Hamann A, Huehn J, Syrbe U.
Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue.
Immunol Cell Biol.2010; 89:566-572.
Bruns S, Kniemeyer O, Hasenberg M, Aimanianda V, Nietzsche S, Thywißen A, Jeron A, Latge JP, Brakhage A, Gunzer M.
Production of Extracellular Traps against Aspergillus fumigatus in vitro and in Infected Lung Tissue is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA.
PLoS Pathog.2010; 6 (4):e1000873.
Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH.
Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation.
Immunity.2010; 33 (1):84-95.
Reichardt P, Dornbach B, Gunzer M.
APC, T Cells, and the Immune Synapse.
Curr Top.Microbiol.Immunol.2010; 340:229-249.
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Koehler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van ZG, Cancelas JA, Zheng Y, Geiger H.
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Nat Med.2010; 16 (10):1141-1146.
Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M.
Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo.
PLoS One. 2011 Feb 23;6(2):e17314.
Josting A, Müller H, Borchmann P, Baars JW, Metzner B, Döhner H, Aurer I, Smardova L, Fischer T, Niederwieser D, Schäfer-Eckart K, Schmitz N, Sureda A, Glossmann J, Diehl V, DeJong D, Hansmann ML, Raemaekers J, Engert A.
Dose Intensity of Chemotherapy in Patients With Relapsed Hodgkin's Lymphoma
J Clin Oncol. 2010 Dec 1;28(34):5074-80. Epub 2010 Oct 25.
Fischer T, Stone RM, Deangelo DJ, Galinsky I, Estey E, Lanza C, Fox E, Ehninger G, Feldman EJ, Schiller GJ, Klimek VM, Nimer SD, Gilliland DG, Dutreix C, Huntsman-Labed A, Virkus J, Giles FJ.
A Phase IIB Trial of Oral Midostaurin (PKC412), the FLT3 and Multi-targeted Kinase Inhibitor, in Patients with Acute Myeloid Leukemia (AML) and high-risk myelodysplastic syndrome (MDS) with Either Wild-Type or Mutated-FLT3.
J Clin Oncol. 2010 Oct 1;28(28):4339-45. Epub 2010 Aug 23.
Kindler T, Lipka DB, Fischer T.
FLT3 as a therapeutic target in AML: still challenging after all these years
Blood. 2010 Dec 9;116(24):5089-102. Epub 2010 Aug 12.
Zizer E, Beilke S, Bäuerle T, Schilling K, Möhnle U, Adler G, Fischer KD, Wagner M.
Gastroenterology.2010; 4: 1344-54.
Bommhardt U.
Hedgehog signalling in T-cell development: a non-redundant role for Gli1.
Cell Cycle.2010; 9:4428
Bickmeyer U, Heine M, Podbielski I, Münd D, Köck M, Karuso P.
Tracking of fast moving neuronal vesicles with ageladine A.
Biochem Biophys Res Commun.2010; 402: 489-94
Mayer-Barber KD, Barber DL, Shenderov K, White S, Feng CG, Cheever A, Kugler D, Hieny S, Caspar P, Iwakura Y, Núñez G, Schlüter D, Flavell RA, Sutterwala FS, Sher A.
Caspase-1 independent IL-1 production is critical for host resistance to Mycobacterium tuberculosis and does not require TLR signaling in vivo.
J. Immunol.2010;184: 3326-3330.
Gopalla N, Sakowicz-Burkiewicz M, Kliche S, Naumann M, Deckert M, Schlüter D.
Protective Toxoplasma gondii-specific T cell responses require T cell-specific expression of protein kinase C-θ.
Infect. Immun.2010; 78: 3454-3464.
Brunn A, Utermöhlen O, Sánchez Ruiz M, Montesinos-Rongen M, Blau T, Schlüter D, Deckert M.
Dual role of B cells with accelerated onset but reduced disease activity in P0106-125-induced experimental autoimmune neuritis of IgH0/0 mice.
Acta Neuropathologica.2010; 120: 667-681.
Swamy M, Siegers GM, Fiala GJ, Molnar E, Dopfer EP, Fisch P, Schraven B, Schamel WW.
Stoichiometry and intracellular fate of TRIM-containing TCR complexex.
Cell Commun Signal.2010 Mar 18;8:5
Rieke C, Kähne T, Schweitzer K, Schraven B, Wienands J, Engelke M, Naumann M.
Non-T cell activation linker regulates ERK activation in helicobacter pylori-infected epithel cells.
Cell Signal.2010 Mar;22(3):395-403.