picture

2013

Arndt B, Poltorak M, Bhavani SK, Reichardt P, Philipsen L, Lindquist JA, Schraven B, Simeoni L. Analysis of TCR activation kinetics in primary human T cells upon focal or soluble stimulation. J Immunol Methods. 2013 Jan 31;387(1-2):276-83.

Arndt B, Kalinski T, Reinhold D, Thielitz A, Roessner A, Schraven B, Simeoni L. Cooperative immunoregulatory function of the transmembrane adaptor proteins SIT and LAX. J Leukoc Biol. 2013 Mar;93(3):353-62.

Atanackovic D, Nowottne U, Freier E, Weber CS, Meyer S, Bartels K, Hildebrandt Y, Cao Y, Kröger N, Brunner-Weinzierl MC, Bokemeyer C, Deter HC. Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders. Stress. 2013 Jul;16(4):421-8.

Caldarelli A, Müller JP, Paskowski-Rogacz M, Herrmann K, Bauer R, Koch S, Heninger AK, Krastev D, Ding L, Kasper S, Fischer T, Brodhun M, Böhmer FD, Buchholz F. A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling. Leukemia. 2013 Dec;27(12):2301-10.

Diesing AK, Nossol C, Faber-Zuschratter H, Zuschratter W, Renner L, Sokolova O, Naumann M, Rothkötter HJ. Rapid interaction of Helicobacter pylori with microvilli of the polar human gastric epithelial cell line NCI-N87. Anat Rec (Hoboken). 2013 Dec;296(12):1800-5.

Dubiel D, Gierisch ME, Huang X, Dubiel W, Naumann M. CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis. Biochim Biophys Acta. 2013 May;1833(5):1078-84.

Engelmann S, Togni M, Thielitz A, Reichardt P, Kliche S, Reinhold D, Schraven B, Reinhold A. T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice. J Immunol. 2013 Nov 15;191(10):4950-9.

Gimsa U, Mitchison NA, Brunner-Weinzierl MC. Immune privilege as an intrinsic CNS property: astrocytes protect the CNS against T-cell-mediated neuroinflammation. Mediators Inflamm. 2013;2013:320519.

Hanssen L, Alidousty C, Djudjaj S, Frye BC, Rauen T, Boor P, Mertens PR, van Roeyen CR, Tacke F, Heymann F, Tittel AP, Koch A, Floege J, Ostendorf T, Raffetseder U. YB-1 is an early and central mediator of bacterial and sterile inflammation in vivo. J Immunol. 2013 Sep 1;191(5):2604-13.

Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Dohner K Vasioukhin V, Fischer T, Armstrong SA. The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. J Exp Med. 2013 Jan 14;210(1):15-22.

Hradsky J, Mikhaylova M, Karpova A, Kreutz MR, Zuschratter W. Super-Resolution Microscopy of the Neuronal Calcium-Binding Proteins Calneuron-1 and Caldendrin. Methods in Molecular Biology, 2013; 963:147-69.

Ivanovska J, Tregubova A, Mahadevan V, Chakilam S, Gandesiri M, Benderska N, Ettle B, Hartmann A, Söder S, Ziesché E, Fischer T, Lautscham L, Fabry B, Segerer G, Gohla A, Schneider-Stock R. Identification of DAPK as a scaffold protein for the LIMK/cofilin complex in TNF-induced apoptosis. Int J Biochem Cell Biol. 2013 Aug;45(8):1720-9.

Karpova A, Mikhaylova M, Bera S, Bär J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell 152: 1119-1133, 2013.
*Research highlight in Nature Reviews Neuroscience.
*Recommended reading Faculty of 1000.

Körmendy D, Hoff H, Hoff P, Bröker BM, Burmester GR, Brunner-Weinzierl MC. The impact of the CTLA-4/CD28 axis on the processes of Joint Inflammation in Rheumatoid Arthritis. Arthritis Rheum. 2013 Jan;65(1):81-7.

Lek HS, Morrison VL, Conneely M, Campbell PA, McGloin D, Kliche S, Watts C, Prescott A, Fagerholm SC. The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow. J Biol Chem. 2013 May 24;288(21):14698-14708

Lindquist JA, Mertens PR. Myofibroblasts, regeneration or renal fibrosis--is there a decisive hint? Nephrol Dial Transplant. 2013 Nov;28(11):2678-81.

Maubach G, Sokolova O, Wolfien M, Rothkötter HJ, Naumann M. Ca2+/calmodulin-dependent kinase II contributes to inhibitor of nuclear factor-kappa B kinase complex activation in Helicobacter pylori infection. Int J Cancer. 2013 Mar 5.133:1507-1512

Mullally A, Bruedigam C, Poveromo L, Heidel F, Purdon A, Vu T, Austin R, Heckl D, Breyfogle L, Kuhn CP, Kalaitzidis D, Armstrong S, Williams D, Hill G, Ebert B, Lane S. Depletion of JAK2V617F MPN-propagating stem cells by interferon-alpha in a murine model of polycythemia vera. Blood. 2013 May 2;121(18):3692-702.

Nishanth G, Deckert M, Wex K, Massoumi R, Schweitzer K, Naumann M, Schlüter D. CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. PLoS Pathog. 2013. 9(6):e1003455.

Patra  A, Avots  A, Zahedi  TR, Schüler  T, Sickmann  A, Bommhardt  U, Serfling  E. A novel NFAT activation pathway mediated by IL-7 is critical for thymocyte development. Nat Immunol. 2013 Feb;14(2):127-35.

Philipsen L, Engels T, Schilling K, Gurbiel S, Fischer KD, Tedford K, Schraven B, Gunzer M, Reichardt P. Multi-molecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clusters. Mol Cell Proteomics. 2013 Jun 10. [Epub ahead of print]

Poltorak M, Arndt B, Kowtharapu BS, Reddycherla AV, Witte V, Lindquist JA, Schraven B, and Simeoni L. TCR activation kinetics and feedback regulation in primary human T cells. Cell Commun Signal. 2013 Jan 14;11(1):4.

Reichardt  P*, Patzak I*, Jones K, Etemire E, Gunzer M*, Hogg N*. A role for LFA-1 in delaying T lymphocyte egress from lymph nodes. EMBO J. 2013 Mar 20;32(6):829-43. * contributed equally

Scheiter M, Lau U, van Ham M, Bulitta B, Groebe L, Garritsen H, Klawonn F, Koenig S, Jansch L. Proteome Analysis of Distinct Developmental Stagesof Human Natural Killer Cells. Mol Cell Proteomics. 2013 May;12(5):1099-114.

Sedding D, Widmer-Teske R, Müller A, Stieger P, Tillmanns HH, Braun-Dullaeus RC. Role of the phosphatase PTEN during vascular remodeling. PLoS One. 2013;8(3):e55445.

Sokolova O, Vieth M, Naumann M. Protein kinase C Isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection. Gut. 2013 Mar;62(3):358-67.

Sokolova O, Borgmann M, Rieke C, Schweitzer K, Rothkötter HJ, Naumann M. Helicobacter pylori induces type 4 secretion system-dependent, but CagA-independent activation of IκBs and NF-κB/RelA at early time points. Int J Med Microbiol. 2013 Dec;303(8):548-52.

Smida M, Cammann C,  Gurbiel S, Kerstin N, Lingel H, Brunner-Weinzierl MC, Suchanek M, Schraven B, and Lindquist JA. PAG/Cbp suppression reveals a novel contribution of CTLA-4 to setting the activation threshold in T cells. Cell Commun Signal. 2013 Apr 19;11(1):28.

Stirnweiss A, Hartig R, Gieseler S, Lindquist JA, Reichardt P, Philipsen L, Simeoni L, Poltorak M, Zuschratter W, Prokazov Y, Paster W, Stockinger H, Harder T, Gunzer M, Schraven B. T cell activation induces local conformational changes of the SRC-family protein tyrosine kinase p56Lck to induce its enzymatic activity. Sci Signal. 2013 Feb 19;6(263):ra13.

van Roeyen CR, Scurt FG, Brandt S, Kuhl VA, Martinkus S, Djudjaj S, Raffetseder U, Royer HD, Stefanidis I, Dunn SE, Dooley S, Weng H, Fischer T, Lindquist JA, Mertens PR. Cold shock Y-box protein-1 proteolysis autoregulates its transcriptional activities. Cell Commun Signal. 2013 Aug 27;11:63.

Wang X, Deckert M, Xuan NT, Nishanth G, Just S, Waisman A, Naumann M, Schlüter D. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol. 2013 Nov;126(5):711-724.

Wang X, Haroon F., Karray S. Deckert M, Schlüter D. Astrocytic Fas ligand-expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis. Eur J Immunol. 2013 Jan;43(1):115-24.

Weinert S, Poitz DM, Auffermann-Gretzinger S, Eger L, Herold J, Medunjanin S, Schmeisser A, Strasser RH, Braun-Dullaeus RC. The lysosomal transfer of LDL/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration. Cardiovasc Res. 2013 Mar 1;97(3):544-52.

Weng HL, Feng DC, Radaeva S, Kong XN, Wang L, Liu Y, Li Q, Shen H, Gao YP, Müllenbach R, Munker S, Huang T, Chen JL, Zimmer V, Lammert F, Mertens PR, Cai WM, Dooley S, Gao B. IFN-γ inhibits liver progenitor cell proliferation in HBV-infected patients and in 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-fed mice. J Hepatol. 2013 Oct;59(4):738-45.

Zenclussen AC, Olivieri DN, Dustin ML, Tadokoro CE. In vivo multiphoton microscopy technique to reveal the physiology of the mouse uterus. Am J Reprod Immunol. 2013 Mar;69(3):281-9.

Zhu C, Mertens PR. Podocytes proliferate: novel mechanism identified in collapsing glomerulopathies. Int Urol Nephrol. 2013 Feb;45(1):275-9.