picture

2010

Albrecht A, Bergado-Acosta JR, Pape HC, Stork O. Role of the neural cell adhesion molecule (NCAM) in amygdalo-hippocampal interactions and salience determination of contextual fear memory. Int J Neuropsychopharmacol. 2010 Jun;13(5):661-74.

Ash MR, Faelber K, Kosslick D, Albert GI,  Roske Y, Kofler M, Schuemann M, Krause E, Freund C. Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes. Structure.2010; 18:944-54.

Augstein A, Poitz DM, Braun-Dullaeus RC, Strasser RH, Schmeisser A. Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells. Cell Mol Life Sci.2010; 68:2627-2642.

Bachmann A, Kobler O, Kittel RJ, Wichmann C, Sierralta J, Sigrist SJ, Gundelfinger ED, Knust E Thomas U. A perisynaptic menage a trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions. J Neurosci.2010; 30:5811-5824.

Backert S, Naumann M. What a disorder: Pro-inflammatory signaling pathways induced by Helicobacter pylori. Trends Microbiol. 2010,18:479-486. *Highlighted in Faculty of 1000 Biology.

Backes A, Seay U, Sedding DG, Tillmanns HH, Braun-Dullaeus RC. Inhibition of matrix deposition: a new strategy for prevention of restenosis after balloon angioplasty. J Cardiovasc Pharmacol.2010; 55:213-218.

Bickmeyer U, Heine M, Podbielski I, Münd D, Köck M, Karuso P. Tracking of fast moving neuronal vesicles with ageladine A. Biochem Biophys Res Commun.2010; 402: 489-94

Bommhardt U. Hedgehog signalling in T-cell development: a non-redundant role for Gli1. Cell Cycle.2010; 9:4428

Brunn A, Utermöhlen O, Sánchez Ruiz M, Montesinos-Rongen M, Blau T, Schlüter D, Deckert M. Dual role of B cells with accelerated onset but reduced disease activity in P0106-125-induced experimental autoimmune neuritis of IgH0/0 mice. Acta Neuropathologica.2010; 120: 667-681.

Bruns S, Kniemeyer O, Hasenberg M,  Aimanianda V, Nietzsche S, Thywißen A, Jeron A,  Latge JP,  Brakhage A, Gunzer M.  Production of Extracellular Traps against Aspergillus fumigatus in vitro and in Infected Lung Tissue is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA. PLoS Pathog.2010; 6 (4):e1000873.

Doebis C, Menning A, Neumann K, Ghani S, Schlawe K, Lauer U, Hamann A, Huehn J, Syrbe U. Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue. Immunol Cell Biol.2010; 89:566-572.

Fischer T, Stone RM, Deangelo DJ, Galinsky I, Estey E, Lanza C, Fox E, Ehninger G, Feldman EJ, Schiller GJ, Klimek VM, Nimer SD, Gilliland DG, Dutreix C, Huntsman-Labed A, Virkus J, Giles FJ. A Phase IIB Trial of Oral Midostaurin (PKC412), the FLT3 and Multi-targeted Kinase Inhibitor, in Patients with Acute Myeloid Leukemia (AML) and high-risk myelodysplastic syndrome (MDS) with Either Wild-Type or Mutated-FLT3. J Clin Oncol. 2010 Oct 1;28(28):4339-45. Epub 2010 Aug 23.

Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V,  Gunzer M, Toellner KM, Elson G, Kosco-Vilbois MH. Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation. Immunity.2010; 33 (1):84-95.

Reichardt P, Dornbach B, Gunzer M. APC, T Cells, and the Immune Synapse. Curr Top.Microbiol.Immunol.2010; 340:229-249.

Gnad T, Feoktistova M, Leverkus M, Lendeckel U, Naumann M. Helicobacter pylori-induced activation of b-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled. Mol Cancer.2010; 9:31          

Gopalla N,  Sakowicz-Burkiewicz M, Kliche S, Naumann M, Deckert M, Schlüter D. Protective Toxoplasma gondii-specific T cell responses require T cell-specific expression of protein kinase C-θ. Infect. Immun.2010; 78: 3454-3464.

Günther S, Schlundt A, Sticht J , Roske Y, Heinemann U, Wiesmüller KH,  Jung G, Falk K, Rötzschke O, Freund C. Bidirectional binding of invariant chain peptides to an MHC class II molecule. Proc Natl Acad Sci U S A.2010; 107:22219-24.

Haase M, Mertens PR. Urinary biomarkers--silver bullets to faster drug development and nephron protection. Nephrol Dial Transplant. 2010 Oct;25(10):3167-9.

Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS One. 2011 Feb 23;6(2):e17314.

Huang SJ, Zenclussen AC, Yang H, Basar M, Chen CO, Arcuri F, Li M, Kayisli U, Buchwalder L, Rahman M, Kocamaz E, Schatz F, Toti P, Lockwood CJ. The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia. Am J Pathol.2010; 177: 2472-2482.

Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, Koch-Nolte F, Boyer O, Seman M, Adriouch S. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med.2010; 207:2561-2568.

Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci U S A.2010; 107:204-209.

Jensen F, Woudwyk M, Teles A, Woidacki K, Taran F, Costa S, Malfertheiner SF, Zenclussen AC. Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation. PLoS One. 2010 Dec 22;5(12):e14409.

Josting A, Müller H, Borchmann P, Baars JW, Metzner B, Döhner H, Aurer I, Smardova L, Fischer T, Niederwieser D, Schäfer-Eckart K, Schmitz N, Sureda A, Glossmann J, Diehl V, DeJong D, Hansmann ML, Raemaekers J, Engert A. Dose Intensity of Chemotherapy in Patients With Relapsed Hodgkin's Lymphoma. J Clin Oncol. 2010 Dec 1;28(34):5074-80. Epub 2010 Oct 25.

Kindler T, Lipka DB, Fischer T. FLT3 as a therapeutic target in AML: still challenging after all these years. Blood. 2010 Dec 9;116(24):5089-102. Epub 2010 Aug 12.

Klages K*, Mayer CT*, Lahl K, Loddenkemper C, Teng MW, Ngiow SF, Smyth MJ, Hamann A, Huehn J*, Sparwasser T*. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res.2010; 70:7788-7799. *equal contribution

Lange, S., M Sylvester, M Schümann, C Freund, and EJ Krause. Identification of phosphorylation-dependent interaction partners of the adapter protein ADAP using quantitative mass spectrometry: SILAC vs (18)O-labeling. J Proteome Res.2010; 9:4113-22.

Leber A, Teles A, Zenclussen AC. Mechanisms of actions of regulatory T cells during pregnancy. Am J Reprod Immunol.2010;63: 445-449.

Licon Luna, RM,  Körmendy D, Brunner-Weinzierl MC. Female-biased incidence of Experimental Autoimmune Encephalomyelistis refects sexual dimorphic expression of CTLA-4 (CD152) on T-lymphocytes. Gender Medicine.2010; 7: 296-308.

Lindquist S, Langnaese K, Karitkina D, Lerch G, Schraven B, Xavier R, Seed B, Lindquist JA. Phosphoprotein associated with glycosphingolipid-enriched microdomains differentially modulates Src kinase activity in brain development. PLoS One,2010; 6(9):e23978.

Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR. YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Biochem Biophys Res Commun. 2010 Jul 30;398(3):482-8.

Mayer-Barber KD, Barber DL, Shenderov K, White S,  Feng CG, Cheever A,  Kugler D, Hieny S, Caspar P, Iwakura Y, Núñez G, Schlüter D,  Flavell RA,  Sutterwala FS, Sher A. Caspase-1 independent IL-1b production is critical for host resistance to Mycobacterium tuberculosis and does not require TLR signaling in vivo. J. Immunol.2010;184: 3326-3330.

Medunjanin S, Weinert S, Poitz D, Schmeisser A, Strasser RH, Braun-Dullaeus RC. Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha. EMBO Rep.2010;11:208-213.

Medunjanin S, Weinert S, Schmeisser A, Mayer D, Braun-Dullaeus RC. Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. Mol Biol Cell.2010; 21:1620-1628.

Menning A, Loddenkemper C, Westendorf AM, Szilagyi B, Buer J, Siewert C, Hamann A, Huehn J. Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. Eur J Immuno.,2010:40:2539-2548.

Polansky JK*, Schreiber L*, Thelemann C, Ludwig L, Krüger M, Baumgrass R,  Cording S, Floess S, Hamann A, Huehn J. Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med.2010; 88:1029-1040. (*equal contribution)

Rauen T, Mertens PR. Unravelling the pathogenesis of lupus nephritis: novel genetic study confirms decisive contribution of circulating colony-stimulating factor-1 (CSF-1). Int Urol Nephrol. 2010 Jun;42(2):519-21.

Rehberg K, Bergado-Acosta JR, Koch J, Stork O. Disruption of fear memory consolidation and reconsolidation by actin filament arrest in the basolateral amygdala. Neurobiol. Learn. Mem. 2010;4:117-26.

Rieke C, Kähne T, Schweitzer K, Schraven B, Wienands J, Engelke M, Naumann M. Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells. Cell Signal.2010; 22:395-403.

Rubio I, Grund S, Shu-Ping S, Biskup C, Bandemer S, Fricke M, Förster M, Graziani A,Wittig U, Kliche S. TCR-Induced Activation of Ras Proceeds at the Plasma Membrane and Requires Palmitoylation of N-Ras. J. Immunol. 2010; 185:3536-3543.

Ryan MA,  Nattamai KJ,  Xing E, Schleimer D, Daria D, Sengupta A, Koehler A,  Liu W, Gunzer M, Jansen M,  Ratner N,  Le Cras TD, Waterstrat A,  Van ZG,  Cancelas JA, Zheng Y, Geiger H. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med.2010; 16 (10):1141-1146.

Schnee B, Marangolo M, Bokemeyer C, Deter HC, Freier E, Weber, CS, Nowottne U, Horn C, Meyer S, Hildebrandt Y, Luetkens T, Cao Y, Pabst C, Muzzulini J, Schnee B, Brunner-Weinzierl MC, Marangolo M, Deter HC, Atanackovic D. Decrease of CD4(+)FOXP3(+) T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor. Psychoneuroendocrinology.2010; 35:663-673.

Schweitzer K, Sokolova O, Bozko PM, Naumann M. Helicobacter pylori induces NF-қB independent of CagA. EMBO Rep.2010; 11:10-11.

Shpacovitch V, Mertens PR. High mobility group box protein-1 crossing cell borders may incite an inflammatory "tornado" in renal disease. Int Urol Nephrol. 2010 Sep;42(3):847-50.

Swamy M, Siegers GM, Fiala GJ, Molnar E, Dopfer EP, Fisch P, Schraven B, Schamel WW. Stoichiometry and intracellular fate of TRIM-containing TCR complexex. Cell Commun Signal.2010 Mar 18;8:5

Sylvester M, Kliche S, Lange S, Geithner S, Klemm C, Schlosser A, Großmann A, Stelzl, Ulrich, Schraven B, Krause E, Freund C. Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells. PLoS 2010; 5:7-18.

Willert M, Augstein A, Poitz DM, Schmeisser A, Strasser RH, Braun-Dullaeus RC. Transcriptional regulation of Pim-1 kinase in vascular smooth muscle cells and its role for proliferation. Basic Res Cardiol.2010; 105:267-277.   

Zaminer J, Brockmann C, Huy P, Opitz R, Reuter C, Beyermann M, Freund C, Müller M, Oschkinat H, Kühne R, Schmalz HG. Addressing protein-protein interactions with small molecules: a Pro-Pro dipeptide mimic with a PPII helix conformation as a module for the synthesis of PRD-binding ligands. Angew Chem Int Ed Engl. 2010; 49:7111-5.

Zenclussen ML, Thuere C, Ahmad N, Wafula PO, Fest S, Teles A, Leber A, Casalis PA, Bechmann I, Priller J, Volk HD, Zenclussen AC. The persistence of paternal antigens in the maternal body is involved in regulatory T-cell expansion and fetal-maternal tolerance in murine pregnancy. Am J Reprod Immunol. 2010;63(3):200-208.

Zhu C, Mertens PR. Epithelial-mesenchymal transition to be or not to be? Is the answer yes and no at the same time? Int Urol Nephrol. 2010 Sep;42(3):843-6.

Zizer E, Beilke S, Bäuerle T, Schilling K, Möhnle U, Adler G, Fischer KD, Wagner M. Loss of Lsc/p115 protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice. Gastroenterology.2010; 4: 1344-54.