picture

2011

Arndt B, Krieger T, Kalinski T, Thielitz A, Reinhold D, Roessner A, Schraven B, Simeoni L. The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS One. 2011;6(9):e23761.

Albert C, Mertens PR, Bartsch P. Urea and atherosclerosis--evidence for a direct link involving apolipoprotein B protein modifications. Int Urol Nephrol. 2011 Sep;43(3):933-6.

Albrecht D, Kniemeyer O, Mech F, Gunzer M, Brakhage A, Guthke R. On the way toward systems biology of Aspergillus fumigatus infection. Int.J Med Microbiol. 2011;301 (5):453-459.

Augstein A, Poitz DM, Braun-Dullaeus RC, Strasser RH, Schmeisser A. Cell-specific and hypoxia-dependent regulation of human HIF-3alpha: inhibition of the expression of HIF target genes in vascular cells. Cell Mol Life Sci.2011; 68:2627-2642.

Beyer T, Busse M, Hristov K, Smida M, Haus U-U, Niermann K, Pfeuffer F, Weismantel R*, Schraven B*, and Lindquist JA*. Integrating signals from the T-cell receptor and the Interleukin-2 receptor. PLoS Comput Biol. 2011;7(8):e1002121.  (*co-senior authors)

Bhattacharyya S, Deb J, Patra AK, Thuy Pham DA, Chen W, Vaeth M, Berberich-Siebelt F, Klein-Hessling S, Lamperti ED, Reifenberg K, Jellusova J, Schweizer A, Nitschke L, Leich E, Rosenwald A, Brunner C, Engelmann S, Bommhardt U, Avots A, Müller MR, Kondo E, Serfling E. NFATc1 affects mouse splenic B cell function by controlling the calcineurin--NFAT signaling network. J Exp Med.2011; 208:823-39.

Blankenhaus B, Klemm U, Eschbach ML, Sparwasser T, Huehn J, Kuhl AA, Loddenkemper C, Jacobs T, Breloer M. Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. J Immunol.2011; 186:4295-4305.

Brandt S, Raffetseder U, Djudjaj S, Schreiter A, Kadereit B, Michele M, Pabst M, Zhu C, Mertens PR. Cold shock Y-box protein-1 participates in signaling circuits with auto-regulatory activities. Eur J Cell Biol. 2012 Jun-Jul;91(6-7):464-71.

Burns JC, Corbo E, Degen J, Gohil M,  Anterasian C,  Schraven B, Koretzky GA,  Kliche S*, Jordan MS*. The SLP-76 Src Homology 2 Domain Is Required for T Cell Development and Activation. J Immunol. 2011;187:4459-66.  * shared senior authorship

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M. Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS. Nat Neurosci. 2011 Dec 4;15(1):98-106. doi: 10.1038/nn.2964.

Dash-Wagh S, Neumann JR, Veitinger S, Grote-Westrick C, Landgraf P, Pape C, Kreutz MR, von Holst A, Wahle P. The survival promoting peptide Y-P30 enhances cellular migration. Mol. Cell.2011;48(3):195-204.

Di Biase V, Tuluc P, Campiglio M, Obermair GJ, Heine M*, Flucher BE*. Surface Traffic of Dendritic CaV1.2 Calcium Channels in Hippocampal Neurons. J Neurosci. 2011;(38):13682-13694 ( *corresponding autors)

Dudeck A, Dudeck J, Scholten J, Petzold A, Surianarayanan S, Köhler A, Peschke K, Voehringer D, Waskow C, Krieg T, Müller W, Waisman A, Hartmann K, Gunzer M, Roers A. Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
Immunity, 2011; 34:973-985.

Engmann O, Hortobagy T, Ridsley P, Troakes C, Bernstein HG, Kreutz MR, Mill J, Nikolic M, Giese KP. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synpatic protein expression and cognition. Brain.2011;34:2408-2421

Fainzilber M, Budnik V, Segal R, Kreutz MR. From Synpase to Nucleus and Back Again - Communication Over Distance Within Neurons. J Neurosci. 2011 Nov 9;31(45):16045-8.

Fischer T. Rethinking bioactivity of FLT3 inhibitors. Blood 2011 Mar 24;117(12):3247-8.

Francke A, Herold J, Weinert S, Strasser RH, Braun-Dullaeus RC. Generation of mature murine monocytes from heterogeneous bone marrow and description of their properties. J Histochem Cytochem.2011; 59:813-825.

Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR. The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011 Apr 26;57(17):1752-61.

Hanssen L, Frye BC, Ostendorf T, Alidousty C, Djudjaj S, Boor P, Rauen T, Floege J, Mertens PR, Raffetseder U. Y-box binding protein-1 mediates profibrotic effects of calcineurin inhibitors in the kidney. J Immunol. 2011 Jul 1;187(1):298-308.

 Haroon F, Drögemüller K, Händel U, Brunn A, Reinhold D, Mueller W, Trautwein C, Ernst M, Karray S, Deckert M, Schlüter D. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J. Immunol.2011;186: 6521-31

Hartmann T, Sasse C, Schedler A, Hasenberg M, Gunzer M, Krappmann S. Shaping the fungal adaptome - Stress responses of Aspergillus fumigatus. Int.J Med Microbiol. 2011;301 (5):408-416.

Hasenberg M,  Behnsen J, Krappmann S, Brakhage A, Gunzer M. Phagocyte responses towards Aspergillus fumigatus. Int.J Med Microbiol. 2011;301 (5):436-444.

Hasenberg M, Köhler A, Bonifatius S, Borucki K, Riek-Burchardt M, Achilles J, Männ L, Baumgart K, Schraven B, Gunzer M. Rapid immunomagnetic negative enrichment of neutrophil granulocytes from murine bone marrow for functional studies in vitro and in vivo. PLoS one.2011;6 (2):e17314.

Hasenberg M, Köhler A, Bonifatius S, Jeron A,Gunzer M. Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy. J Vis.Exp,2011 Jun.; (52):pii: 2659.

Hebel K, Rudolph M, Chan C, Brunner-Weinzierl MC. IL-1β induced human pro-inflammatory T cells are suppressed by TGFβ that again triggers TH17 only by suppression of IFNγ induction. J. Immunol. 2011; 187:5627-5635

Heidel FH, Mack TS, Razumovskaya E, Blum MC, Lipka DB, Ballaschk A, Kramb J-P, Plutizki S, Rönnstrand L, Dannhardt G, Fischer T. 3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells. Ann Hematol. 2012 Mar;91(3):331-44.

Hövelmeyer N,  Reissig S,  Xuan NT,  Adams-Quack P, Lukas D, Nikolaev A, Schlüter D*, Waisman A*. A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur. J. Immunol.2011; 41: 595-601. (* corresponding authors)

Hradsky J, Raghuram V, Reddy PP, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y, Kreutz MR Mikhaylova M. Posttranslational membrane insertion of the tail anchored transmembrane EF-hand Ca2+-sensors Calneurons requires the TRC40/Asna1 chaperone. J Biol Chem. 2011 Oct 21;286(42):36762-76

Kliche, S., T Worbs, X Wang, J Degen, I Patzak, B Meineke, M Togni, M Moser, A Reinhold , F Kiefer , C Freund, R Förster, and B Schraven. CCR7-mediated LFA-1 functions in T cells are regulated by two independent ADAP/SKAP55-modules. Blood. 2012 Jan 19;119(3):777-85

Klippel S, Wieczorek M, Schümann M,  Krause E,  Marg B, Seidel T,  Meyer T, Knapp EW, Freund C. Multivalent Binding of Formin-binding Protein 21 (FBP21)-Tandem-WW Domains Fosters Protein Recognition in the Pre-spliceosome. J Biol Chem. 2011;4;286:38478-87.

Köhler A, De Filippo K, Hasenberg M, van den Brandt C, Nye E, Hosking MP,  Lane TE, Männ L, Ransohoff RM, Hauser AE,  Winter O, Schraven B, Geiger H, Hogg N, Gunzer M. G-CSF mediated Thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood.2011; 117 (16):4349-4357.

Köhler A, Geiger H, Gunzer M. Imaging Hematopoietic Stem Cells in the Marrow of Long Bones In Vivo. Methods Mol.Biol.2011;  750:215-224.

Koehler M, Koehler K, Koenigsmann M, Kreutzmann N, Fischer T, Frommer J. Beyond diagnosis: subjective theories of illness in adult patients with acute myeloid leukemia. Hematology. 2011 Jan;16(1):5-13.

Kolar P, Hoff  H, Maschmeyer P, Burmester GR, Brunner-Weinzierl MC. CTLA-4 (CD152) blockade does not cause a pro-inflammatory cytokine profile in regulatory T cells. Clin. Exp. Rheumatol.2011; 29:254-260.

Lazarevic V, Schöne C, Heine M, Gundelfinger ED, Fejtova A. Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing. J Neurosci.2011; 13: 10189-200

Leber A, Zenclussen ML, Teles A, Brachwitz N, Casalis P, El-Mousleh T, Jensen F,  Woidacki K, Zenclussen AC. Pregnancy; tolerance and suppression of immune responses. Meth Mol Biol.2011;  677: 397-417.

Lindquist S, Hassinger S, Lindquist JA*, and Sailer M*. The balance of proinflammatory and trophic factors in multiple sclerosis patients - effects of acute relapse and immunomudulatory treatment. Mult Scler. 2011;17(7):851-866.  (*co-senior authors)

Liu Y, Meyer C, Müller A, Herweck F, Li Q, Müllenbach R, Mertens PR, Dooley S, Weng HL. IL-13 induces connective tissue growth factor in rat hepatic stellate cells via TGF-β-independent Smad signaling. J Immunol. 2011 Sep 1;187(5):2814-23.

Macharadze T, Landgraf P, Pape HC, Wahle P, Kreutz MR. Y-p30 confers neuroprotection after optic nerve crush in adult rats. NeuroReport.2011,22(11):544-547

Mayer CT, Floess A, Baru AM, Lahl K, Huehn J, Sparwasser T. CD8+Foxp3+ T cells share developmental and phenotypic features with classical CD4+Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immuno.2011; 41:716-725.

Meis S, Stork O,Munsch T. Neuropeptide S-mediated facilitation of synaptic transmission enforces subthreshold theta osciallations within the lateral amygdala. PLoS One.2011; 6:e18020

Mikhaylova M, Hradsky J, Kreutz MR. Between promiscuity and specificity: Novel roles of EF+hand calcium sensors in neuronal Ca2+ signalling. J.Neurochem.2011; 118(5):695-713.

Mondin M, Labrousse V, Hosy E, Heine M,Tessier B, Levet F, Poujol C, Blanchet C, Choquet D, Thoumine O. Neurexin-neuroligin adhesions capture surface-diffusing AMPA receptors through PSD-95 scaffolds. J Neurosci.2011; 31(38):13500-13515

Neish A, Naumann M. Microbial-induced immunomodulation by targeting the NF-κB system. Trends Microbiol. 2011;19:596-605.

Neumann M, Klar S, Wilisch-Neumann A, Hollenbach E, Kavuri S, Leverkus M, Kandolf R, Klingel K*, Brunner-Weinzierl MC*. Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation. Oncogene.2011; 30:2485-2492.

Ocana-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M,  Jessberger R. Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA. J.Immunol. 2011;186 (9):5345-5355.

Pabst M, Mertens PR. What is important to target fibrosis: location, location, location! of cold-shock proteins. Int Urol Nephrol. 2011 Jun;43(2):589-91.

Piotukh K, Geltinger B, Heinrich N,  Gerth F, Beyermann M,  Freund C ,  Schwarzer DJ. Directed evolution of sortase a mutants with altered substrate selectivity profiles. J Am Chem Soc. 2011; 133:17536-9.

Poitz DM, Augstein A, Weinert S, Braun-Dullaeus RC, Strasser RH, Schmeisser A. OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway. Basic Res Cardiol.2011;106:761-772.

Raffetseder U, Rauen T, Boor P, Ostendorf T, Hanssen L, Floege J, En-Nia A, Djudjaj S, Frye BC, Mertens PR. Extracellular YB-1 blockade in experimental nephritis upregulates notch-3 receptor expression and signaling. Nephron Exp Nephrol.2011;118(4):e100-8.

Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K. Dysregulation of Rho GTPases in the {alpha}Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits. Hum Mol Genet. 2012 Jan 15;21(2):268-86.

Rieke C, Papendieck A, Sokolova O, Naumann M. Helicobacter pylori-induced tyrosine phosphorylation of IKKβ contributes to NF-қB activation. Biol Chem. 2011; 392:387-393.

Rudolph M, Hebel K, Miyamura Y, Maverakis E, Brunner-Weinzierl MC. Blockade of CTLA-4 decreases the generation of multifunctional memory CD4+ T cells in vivo. J. Immunol.2011; 186:5580-5589.

Rupp B, Günther S, Makhmoor T , Schlundt A, Dickhaut K, Gupta A, Choudhary I, Wiesmüller KH, Jung G, Freund C, Falk K, Rötzschke O,Kühne R. Characterization of structural features controlling the receptiveness of empty class II MHC molecules. PLoS One. 2011; 6:e18662.

Schönfeld P, Schlüter T, Fischer KD, Reiser G. Non-esterified polyunsaturated fatty acids distinctly modulate the mitochondrial and cellular ROS production in normoxia and hypoxia. J Neurochem.2011; 118(1): 69-78.

Soldati R, Berger E, Zenclussen AC, Jorch G, Lode HN, Salatino M, Rabinovich GA, Fest S. Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments. Int J Cancer doi: 10.1002/ijc.26498

Steinfelder S, Floess S, Engelbert D, Haeringer B, Baron U, Rivino L, Steckel B,  Gruetzkau A, Olek S, Geginat J, Huehn J, Hamann A. Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood.2011; 117:2839-2846. (*equal contribution)

Stephanowitz  H,  Lange S,  Lang D , Freund C, Krause EJ. An improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions. J Proteome Res. 2012 Feb 3;11(2):1175-83

Tacke F, Kanig N, En-Nia A, Kaehne T, Eberhardt CS, Shpacovitch V, Trautwein C, Mertens PR. Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease. BMC Cancer. 2011 May 20;11:185.

Toker A, Huehn J. To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. Sci Signal.2011;4:pe4. 

Vitali M, Picazo F, Prokazov Y, Duci A, Turbin E, Götze C, Llopis J, Hartig R, Visser AJ, Zuschratter W. Wide-Field Multi-Parameter FLIM: long-term minimal invasive observation of proteins in living cells. PLoS One. 2011 Feb 2;6(2):e15820.

Wienecke J, Hebel K, Hegel K, Pierau M, Brune T, Reinhold D, Pethe A, Brunner-Weinzierl MC. Pro-inflammatory effector Th cells transmigrate through anti-inflammatory environments into the murine fetus. Placenta. 2012 Jan;33(1):39-46

Wu YJ, Cai WM, Li Q, Liu Y, Shen H, Mertens PR, Dooley S, Weng HL. Long-term antifibrotic action of interferon-γ treatment in patients with chronic hepatitis B virus infection. Hepatobiliary Pancreat Dis Int. 2011 Apr;10(2):151-7.

Zenclussen ML, Casalis PA, El-Mousleh T, Rebelo S, Linzke N, Langwisch S, Volk HD, Fest S, Soares MP, Zenclussen AC. Heme Oxygenase-1 dictates intrauterine fetal survival in mice via carbon monoxide. J Pathol.2011;225: 293-304.