B 16 - Control of immunological synapse formation in Tregs

Regulatory T cells (Tregs) critically rely on the TCR signaling network to realize both their development and immunosuppressive function. This project will investigate the impact of newly identified candidate regulators of cytoskeleton dynamics and molecular transport for the unique assembly of TCR signaling components at the Treg-specific immunological synapse, and additionally will study the regulation and functional consequences of microvesicle transexocytosis from Tregs to antigen-presenting cells. Thereby, B 16 will pave the way for targeting of molecular transport in Tregs to modulate their immunosuppressive properties.